Scientific publications since 2006

1. Villalobos C, Sobradillo D, Hernández-Morales M, Núñez L (2017).
Calcium remodeling in colorectal cancer. Biochim Biophys Acta Mol Cel Res (in press).

2. Calvo-Rodríguez M, de la Fuente C, García-Durillo M, García-Rodríguez C, Villalobos C, Núñez L (2017).
Aging and amyloid β oligomers enhance TLR4 expression, LPS-induced Ca2+ responses and neuron cell death in cultured rat hippocampal neurons. J Neuroinflammation 14:24. 

3. Diaz-Soto G, Rocher A, García-Rodríguez C, Núñez L, Villalobos C (2016)
The calcium-sensing receptor in health and disease. Int Rev Cell Mol Biol 327, 321-369.  

4. Calvo-Rodríguez M, García-Durillo M, Villalobos C, Núñez L (2016)
In vitro aging promotes endoplasmic reticulum (ER)-mitochondria Ca2+ cross talk and loss of store-operated Ca2+ entry (SOCE) in rat hippocampal neurons. Biochim Biophys Acta Mol Cel Res 1863(11): 2637-2649.

5. Calvo-Rodríguez M, García-Durillo M, Villalobos C, Núñez L (2016)
Aging enables Ca2+ overload and apoptosis induced by amyloid-β oligomers in rat hippocampal neurons: neuroprotection by non-steroidal anti-inflammatory drugs and R-flurbiprofen in aging neurons. J Alzheimers Dis 54(1):207-221.

6. Villalobos C, Sobradillo D, Hernández-Morales M, Núñez L (2016)
Remodeling of calcium entry pathways in cancer. Adv Exp Med Biol 898:449-66.

7. Caballero E, Calvo-Rodriguez M, Gonzalo-Ruiz A, Villalobos C, Núñez L (2016)
A new procedure for amyloid β oligomers preparation enables the unambiguous testing of their effects on cytosolic and mitochondrial Ca2+ entry and cell death in primary neurons. Neurosci Lett 612, 66–73. 

8. Calvo-Rodríguez M, Villalobos C, Nuñez L (2015)
Fluorescence and bioluminescence imaging of subcellular Ca2+ in aged hippocampal neurons. J Vis Exp (JoVE) 106, e53330. 

9. Calvo-Rodríguez M, Núñez L, Villalobos C (2015)
Non-steroidal anti-inflammatory drugs (NSAIDs) and neuroprotection in the elderly: a view from the mitochondria. Neural Regen Res 10 (9), 1371-1372. 

10. Senovilla L, Núñez L, de Campos JM, de Luis DA, Romero E, García-Sancho J, Villalobos C (2015)
Single-cell phenotypic characterization of human pituitary GHomas and non-functioning adenomas based on hormone content and calcium responses to hypothalamic releasing hormones. Front Oncol 5, 124. 

11. Calvo M, Sanz-Blasco S, Caballero E, Villalobos C, Núñez L (2015)
Susceptibility to excitotoxicity in aged hippocampal cultures and neuroprotection by non-steroidal anti-inflammatory drugs: role of mitochondrial calcium. J Neurochem 132 (4), 403-417.  

12. Calvo M, Villalobos C, Núñez L (2015)
Calcium imaging in neuron cell death. Methods Mol Biol 1254, 73-85.

13. Sobradillo D, Hernández-Morales M, Ubierna D, Moyer MP, Núñez L, Villalobos C (2014)
A reciprocal shift in transient receptor potential channel 1 (TRPC1) and stromal interaction molecule 2 (STIM2) contributes to Ca2+ remodeling and cancer hallmarks in colorectal carcinoma cells. J Biol Chem 289, 28765-28782. 

14. Jara E, Hidalgo MA, Hancke JL, Hidalgo AI, Brauchi S, Nuñez L, Villalobos C, Burgos RA (2014)
Delphinidin activates NFAT and induces IL-2 production through SOCE in T cells. Cell Biochem Biophys 68, 497-509. 

15. Muñoz E, Hernández-Morales M, Sobradillo D, Rocher A, Núñez L, Villalobos C (2013)
Intracellular Ca2+ remodeling during the phenotypic journey of human coronary smooth muscle cells. Cell Calcium 54:375-85. 

16. Gautier CA, Giaime E, Caballero E, Núñez L, Song Z, Chan D, Villalobos C, Shen J (2012)
Regulation of mitochondrial permeability transition pore by PINK1. Mol Neurodegener May 25; 7(1):22.

17. Perez-Alvarez S, Solesio ME, Cuenca-Lopez MD, Melero-Fernández de Mera RM, Villalobos C, Kmita H, Galindo MF, Jordán J (2012)
Pharmacological characterization of the mechanisms Involved in delayed calcium deregulation in SH-SY5Y cells challenged with methadone. Int J Cell Biol 2012: 642482.

18. Villalobos C, Caballero E, Sanz-Blasco S, Núñez L (2012)
Study of neurotoxic intracellular calcium signalling triggered by amyloids. Methods Mol Biol 849: 289-302.

19. Núñez J, Sanz-Blasco S, Vignoletti F, Muñoz F, Arzate H, Villalobos C, Nuñez L, Caffesse RG, Sanz M (2012)
Periodontal regeneration following implantation of cementum and periodontal ligament-derived cells. J Periodontal Res 47(1):33-44.

20. Quintana A, Pasche M, Junker C, Al-Ansary D, Rieger H, Kummerow C, Nuñez L, Villalobos C, Meraner P, Becherer U, Rettig J, Niemeyer BA, Hoth M (2011)
Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T-cell activation. EMBO J 30(19):3895-3912. 

21. Muñoz E, Valero RA, Quintana A, Hoth M, Núñez L, Villalobos C (2011)
Non-steroidal anti-inflammatory drugs inhibit vascular smooth muscle cell proliferation by enabling the Ca2+-dependent inactivation of Ca2+ release-activated Ca2+/Orai channels normally prevented by mitochondria. J Biol Chem 286, 16186-16196. 

22. Molina-Guijarro JM, Macías A, García C, Muñoz E, García-Fernández LF, David M, Lillo MP, Núñez L, Martínez-Leal JF, Moneo V, Cuevas C, Villalobos Jorge C, Valenzuela C, Galmarini CM (2011)
Irvalec inserts in the plasma membrane, causing rapid loss of integrity and necrotic cell death in tumor cells.  PLoS One 6(4): e19042.

23. Núñez J, Sanz-Blasco S, Vignoletti F, Muñoz F, Caffesse RG, Sanz M, Villalobos C, Núñez L (2010)
17-estradiol promotes cementoblast proliferation and cementum formation in experimental periodontitis. J Periodontol 81, 1064-1074. 

24. Núñez L, Villalobos C, Alonso MT, García-Sancho J (2010)
Ca2+ imaging of intracellular organelles:  Mitochondria. In “Calcium measurement methods. Neuromethods (Humana Press) Editors: Alexei Verkhratsky and Ole H. Petersen. 43, 169-188.  

25. García E, Sanz-Blasco S, Karachitos A, Bández M, Fernández-GómezFJ, Pérez-Alvarez S, Melero Fernández de Mera RM, Jordán MJ, Aguirre N, Galindo MF, Villalobos C, Navarro A, Kmita H, Jordán J (2010)
Mitochondria and calcium flux as targets of neuroprotection caused by minocycline in cerebellar granule cells. Biochem Pharmacol 79, 239-250. 

26. Villalobos C, Alonso MT, García-Sancho J (2009)
Bioluminescence imaging of calcium oscillations inside intracellular organelles. Methods Mol Biol 574, 203-214. 

27. Atwood C, Bacskai B, Kuchibhotla K, Bezprozvanny I, Chakroborty S, Fagan T, Foskett K, Green K, Goussakov I, Moyer J, Michno K, Rybalchenko V, Stutzmann B, Villalobos C (2009)
Alzheimer research forum live discussion: calcium in AD pathogenesis. J Alzheimers Dis 16, 909-917. 

28. Ordóñez-Morán P, Palmer HG, Larriba MJ, Valero RA, Barbáchano A, Dunach M, García de Herreros A, Villalobos C, Berciano MT, Lafarga M, Múñoz A (2008)
RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype and Wnt pathway in colon cancer cells. J Cell Biol 183, 697-710. 

29. Valero RA, Senovilla L, Núñez L, Villalobos C (2008)
The role of mitochondrial potential in control of calcium signals involved in cell proliferation. Cell Calcium 44, 259-269. 

30. Sanz-Blasco S, Valero RA, Rodríguez-Crespo I, Villalobos C, Núñez L (2008)
Mitochondrial Ca2+ overload underlies Aβ oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs. PLoS ONE 3(7): e2718. 

31. Senovilla L, Núñez L, Villalobos C, García-Sancho J (2008)
Rapid changes in anterior pituitary cell phenotypes in male and female mice after acute cold stress. Endocrinology 149, 2159-2167. 

32. Núñez L, Villalobos C, García-Sancho J (2008)
Coupling or not coupling of mitochondria to Ca2+ sources in neurones. Soma and neurites differ. Physiol News 70, spring 2008, pp 23-24. 

33. Chamero P, Manjarres IM, García-Verdugo JM, Villalobos C, Alonso MT, García-Sancho J (2008) 
Nuclear calcium signalling by inositol trisphosphate in GH3 pituitary cells. Cell Calcium 43, 205-214.

34. Quesada I, Villalobos C, Núñez L, Chamero P, Alonso MT, Nadal A, García-Sancho J (2008)
Glucose induces synchronous mitochondrial calcium oscillations in intact pancreatic islets. Cell Calcium 43, 39-47.

35. Núñez L, Senovilla L, Sanz-Blasco SI, Chamero P, Alonso MT, Villalobos C, García-Sancho J (2007)
Bioluminescence imaging of mitochondrial Ca2+ dynamics in soma and neurites of individual adult mouse sympathetic neurons.. J Physiol (Lond) 580, 385-395.

36. Alonso MT, Villalobos C, Chamero P, Alvarez J, García-Sancho J (2006)
Calcium microdomains in mitochondria and nucleus. Cell Calcium 40, 513-525. 

37. Núñez L, Valero RA, Senovilla L, Sanz-Blasco S, García-Sancho J, Villalobos C (2006)
Cell proliferation depends on mitochondrial Ca2+ uptake: inhibition by salicylate. J Physiol (Lond) 571, 57-73.