Calcium remodeling
in cancer


Cell transformation in cancer is associated to metabolic and phenotypic changes named cancer hallmarks including enhanced cell proliferation, migration, invasion and survival. Recently, evidence indicates that some, if not all, these changes are related to the remodeling of intracellular Ca2+ homestasis. We used well characterized normal and cancer cell lines to establish the cell and molecular basis of calcium remodeling in colon and pancreatic cancer as well as its contribution to cancer hallmarks.